AB0304 LEVELS AND TRENDS IN PREMATURE MORTALITY BURDEN DUE TO SYSTEMIC LUPUS ERYTHEMATOSUS IN CUBA

Background: Analysis of the causes premature mortality is an essential function public health surveillance. A variety methods have been used to accurately assess and report level trends mortality; however, many significant limitations, particularly in capturing actual early deaths. Years life lost (YLL) has recognized as a robust comprehensive measure mortality. 1 Systemic lupus erythematosus (SLE) among leading burden young women United States from SLE increasing Latin America. 2, 3 However, not fully characterized Cuba. Objectives: To identify levels due Cuba during 2001-2018. Methods: Data were obtained database Ministry Public Health (International Classification Diseases-10, code 32 underlying cause death). YLL calculated using standard expectancy WHO’s global estimates. Age- sex-specific rates Cuban mid-year population estimates age-standardized rate (ASYR) was estimated by direct method population. The 2001-2018 temporal analyzed Jointpoint software. Results: During 2001-2018, 475 patients died SLE. These deaths contributed 66 605 (women= 59 166; men=7 433), with mean 45.1 per death 45.2; men= 44.5). 40-44 age group most affected both sexes 9 266 (women=8 177; men=1 086). ASYR higher 2018 than 2001 for (Figure 1). significantly trend identified throughout period (average annual percent change [AAPC] =1.9; 95% confidence interval [CI] = 0.9 3.0), more pronounced men (AAPC 7.0; CI 3.5 10.6) 1.3; 0.3 2.3). Conclusion: high growing Cuba, demands its recognition important problem immediate actions that help mitigate it. References: [1]Martinez R, Soliz P, Caixeta Ordunez P. Reflection on modern methods: years mortality-a versatile monitoring non-communicable disease Int J Epidemiol. 2019; 48(4): 1367-1376. [2]Yen EY, Singh RR. Lupus - unrecognized women: Population-based study nationwide certificates, 2000-2015. Arthritis Rheumatol. 2018;70:1251–5. [3]Soares CR, Viana K, Moraes-Santos F, Vieira CL, Lamarão Iglesias-Rodriguez M. Mortality systemic America US England Wales. Value Health. 2015;18:A805–81. Disclosure Interests: None declared